Keith Urban joins an all-star cast for the 10th Anniversary of Stand Up to Cancer, a telethon first airing in 2008 by media and entertainment leaders to help raise money and awareness for cancer research and assist in funding innovative treatments. The organization has already raised more than $480 million.

Academy Award-nominated actor Bradley Cooper will serve as executive producer for the special, while others participating in the telecast include Reese Witherspoon, Kathy Bates, co-founder Katie Couric, Jennifer Garner, Matthew McConaughey, Mahershala Ali, David Spade, Tony Hale, Marlee Matlin, Ken Jeong, Jillian Michaels and many others.

Stand Up to Cancer will air commercial-free on September 7th at 8pm ET/PT on numerous networks, including ABC, CBS, NBC, FOX, Bravo, Freeform, FXM, HBO, ION, REELZ, Showtime, STARZ, Encore, TNT and WGN America, among others.